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Cough is a very frequent symptom is children, and a usual cause for medical appointment. According to its duration, cough can be classified as acute, subacute or chronic. Patients must be evaluated systematic and rationally. Empirical therapy can be considered in suspected infections, asthma, gastro-oesophageal reflux and posterior rhinorrhoea. Symptomatic therapy in children includes central or peripheral antitussives, demulcents and mucolytics. Scientific evidence for their use is very scarce, but they can be considered to ameliorate comfort in children older than two years-old, for short periods, and integrated in an investigation and medical revaluation plan.