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Abstract

Acute adrenal crisis is a rare but severe condition. Clinical symptoms are diverse and non-specific, therefore, the diagnosis of this condition relies heavily on a high level of clinical suspicion and should be considered, if relevant, regardless of the patient's medical history. Timely treatment is crucial to the survival of patients with this condition. The case of a woman with a history of adrenal insufficiency due to non-classic 21-hydroxylase deficiency exemplifies the importance of recognizing warning signs that may indicate an acute adrenal crisis.This condition is life-threatening and can be initially assessed in the context of primary healthcare, making it essential for family physicians to be aware of this condition and how to prevent it and recognize it promptly. The failure to adjust chronic corticosteroid therapy in the face of respiratory infection was likely the triggering factor for the acute adrenal crisis.