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COVID-19 pandemic caused unprecedented changes in society. Technological innovation enhanced pandemic crisis approach by improving detection, monitoring and mitigation of infection’s impact. Simultaneously, compliance with healthcare authorities’ guidelines challenged conventional patient-physician relationship, fostering the transition to a new digital paradigm of healthcare by the implementation of telehealth solutions (teleconsultation). In this essay, we analyze the impact of technological innovation in addressing COVID-19 crisis, its impact on the digital transformation of CUF healthcare and we envision a future vision of our customer’s journey, aware that the opportunity triggered by this crisis for this transformation will allow clinical efficiency and quality gains, by a new technological architecture that promotes a preventive, predictive and personalized medicine.