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Allergy to cow’s milk proteins is common, serious and of growing persistence. A milk-free diet is difficult to comply with and the potentially serious adverse reactions associated with accidentally ingesting the product are frequent. We discuss the clinical case of a six-year-old child with a personal history of allergies to cow’s milk proteins since three months old, with various episodes of anaphylaxis caused by the accidental ingestion of cow’s milk. At the age of four the child was successfully submitted to cow’s milk tolerance induction methods, allowing the child now to have a free diet. This therapeutic strategy is revolutionary as it allows the natural history of serious and persistent allergy to cow’s milk to be modified, with a very positive impact on the quality of life of the patients and their families.