Whipple disease is a rare multisystemic infection caused by the gram-positive bacillus Tropheryma whipplei. Diagnosis is difficult due to the nonspecific initial symptoms and its delay invariably affects the prognosis. This case highlights the importance of the family doctor's high index of suspicion and his role in the prompt diagnosis of a rare pathology. We present the case of a 66-year-old man initially evaluated in primary care for mandibular swelling. The diagnosis of Whipple's disease was made 2 months later, when new symptoms appeared, and the Family Doctor requested more targeted complementary diagnostic exams. Rapid coordination with hospital care in an urgent context proved to be an efficient weapon in approaching this clinical case, allowing quick initiation of antibiotic therapy, which consequently provided a favorable prognosis for the patient.

We examined the history and the impact of the Institute of Molecular Pathology and Immunology of the University of Oporto (IPATIMUP), one of Portugal’s most influential scientific institutions. Based on interviews with researchers and collaborators, as well as on an extensive review of bibliographic and institutional sources, this study explores the motivations behind its creation, the challenges faced, and the scientific achievements and collaborations that shaped its trajectory.
By integrating research, education, and service provision, the Institute has become a model of excellence in the biomedical field. This work highlights its role in advancing Science, Medicine and Health Literacy, while also addressing its future challenges and opportunities.